45 Mp Lante M E D Dical Demces General Aspects of Pathogenesis
نویسندگان
چکیده
Implantation of prosthetic material evokes a host response, which intrinsically increases the risk of infection. Animal models have shown that the inoculum needed to establish infection is greatly reduced in the presence of a foreign body.' The characteristics of the implanted device and the material from which it is manufactured, the likelihood that the device might be exposed to micro-organisms, the intrinsic virulence of the involving organisms and the capacity of the host to resist infection all contribute to the overall risk of device related infection. `Biomaterial' is a generic term for the material from which a medical device, manufactured for the distinct purpose of implantation in the human body, is constructed. Most devices are constructed of hydrocarbon polymers, which can now be engineered with predictable mechanical properties. Biomaterial in contact with deep tissues can have one or more physiologic effects: 2
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